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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318589
Species: Mus musculus
RGD Object: Gene
Symbol: Hsd3b1
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd3b1decreases expressionEXP 6480464CTDMethoxychlor results in decreased expression of HSD3B1 mRNAPMID:21514315
Hsd3b1increases expressionISOHSD3B1 (Homo sapiens)6480464CTDMethoxychlor results in increased expression of HSD3B1 mRNAPMID:12858341
Hsd3b1multiple interactionsISOHsd3b1 (Rattus norvegicus)6480464CTDMethoxychlor metabolite inhibits the reaction [FSHB protein results in increased expression of HSD3B1 mRNA]PMID:16737795
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