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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10765
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDMethoxychlor metabolite results in decreased expression of IGF1 mRNAPMID:11509743
Igf1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of IGF1 mRNAPMID:11509743
Igf1decreases expressionISOIgf1 (Rattus norvegicus)6480464CTDMethoxychlor results in decreased expression of IGF1 mRNAPMID:21782745
Igf1increases expressionISOIgf1 (Rattus norvegicus)6480464CTDMethoxychlor results in increased expression of IGF1 mRNAPMID:27103539
Igf1increases methylationISOIgf1 (Rattus norvegicus)6480464CTDMethoxychlor results in increased methylation of IGF1 genePMID:23303685
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