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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352010
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:68233
Term: (Z)-3-butylidenephthalide
Definition: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity.
Chemical ID: MESH:C026105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK2decreases expressionEXP 6480464CTDbutylidenephthalide results in decreased expression of CDK2 proteinPMID:16987298 PMID:23770345
CDK2decreases expressionISOCdk2 (Rattus norvegicus)6480464CTDbutylidenephthalide results in decreased expression of CDK2 proteinPMID:16987298
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