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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:68232
Term: (Z)-ligustilide
Definition: A butenolide that has formula C12H14O2.
Chemical ID: MESH:C027820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [ligustilide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [ligustilide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]; ligustilide inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; ligustilide inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; ligustilide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; ligustilide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]PMID:33130971
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