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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731982
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Acc ID: CHEBI:6820
Term: methapyrilene
Definition: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Chemical ID: MESH:D008701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnma1affects methylationISOKCNMA1 (Homo sapiens)6480464CTDMethapyrilene affects the methylation of KCNMA1 intronPMID:30157460
Kcnma1decreases expressionISOKCNMA1 (Homo sapiens)6480464CTDMethapyrilene results in decreased expression of KCNMA1 mRNAPMID:31555880
Kcnma1increases expressionISOKCNMA1 (Homo sapiens)6480464CTDMethapyrilene results in increased expression of KCNMA1 mRNAPMID:35690182
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