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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620993
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nucks1
Name: nuclear casein kinase and cyclin-dependent kinase substrate 1
Acc ID: CHEBI:6820
Term: methapyrilene
Definition: A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group.
Chemical ID: MESH:D008701
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMethapyrilene results in decreased expression of NUCKS1 mRNA

PMID:30467583
increases methylationISORGD:7361626480464CTDMethapyrilene results in increased methylation of NUCKS1 intron

PMID:30157460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.