GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Snca | affects localization | EXP | | 6480464 | CTD | Methamphetamine affects the localization of SNCA protein modified form | PMID:32569805 | Snca | affects response to substance | EXP | | 6480464 | CTD | SNCA affects the susceptibility to Methamphetamine | PMID:12732244 | Snca | increases expression | EXP | | 6480464 | CTD | Methamphetamine results in increased expression of SNCA protein | PMID:16181420 PMID:31783120 PMID:32278788 PMID:32569805 PMID:34562559 | Snca | increases response to substance | EXP | | 6480464 | CTD | SNCA protein results in increased susceptibility to Methamphetamine | PMID:32278788 | Snca | multiple interactions | EXP | | 6480464 | CTD | [SNCA protein co-treated with Methamphetamine] results in decreased expression of NR4A2 protein; [SNCA protein co-treated with Methamphetamine] results in increased expression of IL1B protein; [SNCA protein co-treated with Methamphetamine] results in increased expression of IL6 protein; [SNCA protein co-treated with Methamphetamine] results in increased expression of NFKB1 protein; [SNCA protein co-treated with Methamphetamine] results in increased expression of TNF protein; MAPT protein affects the reaction [Methamphetamine results in increased expression of SNCA protein]; Methamphetamine results in increased expression of and results in increased phosphorylation of SNCA protein; SNCA gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of RBFOX3 protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of CDK5 protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of GFAP protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of GSK3B protein modified form]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of MAPT protein modified form]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of SNCA protein]; SNCA protein affects the reaction [Methamphetamine results in decreased expression of CNP protein]; SNCA protein affects the reaction [Methamphetamine results in decreased expression of MBP protein]; SNCA protein affects the reaction [Methamphetamine results in decreased expression of TFEB protein]; SNCA protein affects the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of MAPT protein]; SNCA protein affects the reaction [Methamphetamine results in increased expression of SQSTM1 protein]; SNCA protein affects the reaction [Methamphetamine results in increased phosphorylation of MTOR protein]; TFEB protein inhibits the reaction [Methamphetamine results in increased expression of SNCA protein] | PMID:31783120 PMID:32278788 PMID:32569805 PMID:34562559 | Snca | affects localization | ISO | SNCA (Homo sapiens) | 6480464 | CTD | Methamphetamine affects the localization of SNCA protein modified form | PMID:32569805 | Snca | increases expression | ISO | Snca (Rattus norvegicus) | 6480464 | CTD | Methamphetamine results in increased expression of SNCA protein | PMID:17904249 PMID:25090657 PMID:28661099 PMID:31059759 | Snca | increases expression | ISO | SNCA (Homo sapiens) | 6480464 | CTD | Methamphetamine results in increased expression of SNCA protein | PMID:31059759 PMID:31783120 | Snca | increases response to substance | ISO | SNCA (Homo sapiens) | 6480464 | CTD | SNCA gene SNP results in increased susceptibility to Methamphetamine | PMID:15542733 | Snca | multiple interactions | ISO | Snca (Rattus norvegicus) | 6480464 | CTD | CEBPB protein affects the reaction [Methamphetamine results in increased expression of SNCA protein]; Methamphetamine promotes the reaction [SNCA protein binds to SNCA protein] | PMID:25090657 PMID:31059759 | Snca | multiple interactions | ISO | SNCA (Homo sapiens) | 6480464 | CTD | PRKN protein inhibits the reaction [Methamphetamine results in increased expression of SNCA protein]; SNCA protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; SNCA protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; SNCA protein affects the reaction [Methamphetamine results in increased cleavage of PARP1 protein]; SNCA protein affects the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of MAPT protein]; SNCA protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; TRIB3 protein affects the reaction [Methamphetamine results in increased expression of SNCA protein] | PMID:31059759 PMID:31783120 | | ||||||||||||||||||||||
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