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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734103
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1H4
Name: nuclear receptor subfamily 1 group H member 4
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1H4increases expressionISONr1h4 (Mus musculus)6480464CTDMethamphetamine results in increased expression of NR1H4 mRNA; Methamphetamine results in increased expression of NR1H4 proteinPMID:35688268
NR1H4multiple interactionsISONr1h4 (Mus musculus)6480464CTDobeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 mRNA]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of NR1H4 protein]PMID:35688268
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