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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733713
Species: Mus musculus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4increases expressionISOAtf4 (Rattus norvegicus)6480464CTDMethamphetamine results in increased expression of ATF4 mRNA; Methamphetamine results in increased expression of ATF4 proteinPMID:19564919
Atf4increases expressionISOATF4 (Homo sapiens)6480464CTDMethamphetamine results in increased expression of ATF4 proteinPMID:27323860
Atf4multiple interactionsISOAtf4 (Rattus norvegicus)6480464CTDSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of ATF4 protein]PMID:19564919
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTDATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ATF4 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein]; ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]; EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of ATF4 protein]PMID:27323860
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