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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68431
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn5
Name: claudin 5
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn5decreases expressionEXP 6480464CTDMethamphetamine results in decreased expression of CLDN5 mRNAPMID:19564919
Cldn5decreases expressionISOCldn5 (Mus musculus)6480464CTDMethamphetamine results in decreased expression of CLDN5 mRNA; Methamphetamine results in decreased expression of CLDN5 proteinPMID:35390362 PMID:36720452
Cldn5multiple interactionsISOCldn5 (Mus musculus)6480464CTD[Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 mRNA]; [Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]PMID:35390362 PMID:36720452
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