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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageEXP 6480464CTDMethamphetamine results in increased cleavage of CASP12 protein

PMID:28070110
increases expressionEXP 6480464CTDMethamphetamine results in increased expression of CASP12 mRNA, Methamphetamine results in increased expression of CASP12 protein

PMID:28619521, PMID:29705343
multiple interactionsEXP 6480464CTDCDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein], Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]

PMID:28070110, PMID:29705343
increases expressionISORGD:13480776480464CTDMethamphetamine results in increased expression of CASP12 protein

PMID:29705343
multiple interactionsISORGD:13480776480464CTDCDK5 protein affects the reaction [Methamphetamine results in increased expression of CASP12 protein]

PMID:29705343
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.