GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tlr4 | increases expression | EXP | | 6480464 | CTD | Methamphetamine results in increased expression of TLR4 protein | PMID:30450033 | Tlr4 | multiple interactions | EXP | | 6480464 | CTD | Lactulose inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein] | PMID:30450033 | Tlr4 | increases expression | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | Methamphetamine results in increased expression of TLR4 mRNA; Methamphetamine results in increased expression of TLR4 protein | PMID:32768653 PMID:33359793 PMID:35390362 PMID:35688268 PMID:36720452 | Tlr4 | multiple interactions | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | [Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in increased expression of TLR4 mRNA]; [Neomycin co-treated with Metronidazole co-treated with Ampicillin co-treated with Vancomycin] inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of TLR4 protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of CLDN5 protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of OCLN protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of TJP1 mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in decreased expression of TJP1 protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of MYD88 mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of MYD88 protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of RELA mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of RELA protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of TRAF6 mRNA]; TLR4 gene mutant form inhibits the reaction [Methamphetamine results in increased expression of TRAF6 protein] | PMID:35390362 PMID:35688268 PMID:36720452 | | ||||||||||||||||||||||
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