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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a4
Name: solute carrier family 6 member 4
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a4decreases expressionEXP 6480464CTDMethamphetamine results in decreased expression of SLC6A4 proteinPMID:15900317
Slc6a4increases response to substanceEXP 6480464CTDSLC6A4 protein results in increased susceptibility to MethamphetaminePMID:10684896
Slc6a4affects expressionISOSlc6a4 (Mus musculus)6480464CTDMethamphetamine affects the expression of SLC6A4 proteinPMID:11093760 PMID:9369336
Slc6a4affects response to substanceISOSlc6a4 (Mus musculus)6480464CTDSLC6A4 mRNA affects the susceptibility to MethamphetaminePMID:19689456
Slc6a4decreases expressionISOSLC6A4 (Homo sapiens)6480464CTDMethamphetamine results in decreased expression of SLC6A4 proteinPMID:16389202 PMID:18841348
Slc6a4multiple interactionsISOSlc6a4 (Mus musculus)6480464CTDIL6 protein affects the reaction [Methamphetamine affects the expression of SLC6A4 protein]; TRP53 protein affects the reaction [Methamphetamine affects the expression of SLC6A4 protein]PMID:11093760 PMID:9369336
Slc6a4multiple interactionsISOSLC6A4 (Homo sapiens)6480464CTDCitalopram inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; indatraline inhibits the reaction [SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; SLC6A4 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]PMID:17234900
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