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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557983
Species: Mus musculus
RGD Object: Gene
Symbol: Grm2
Name: glutamate receptor, metabotropic 2
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grm2multiple interactionsEXP 6480464CTD[Piperidines results in increased activity of GRM2 protein] which results in decreased susceptibility to MethamphetaminePMID:21366332
Grm2increases response to substanceISOGRM2 (Homo sapiens)6480464CTDGRM2 gene SNP results in increased susceptibility to MethamphetaminePMID:20211215
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