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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10796
Species: Mus musculus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:6807
Term: methadone
Definition: A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
Chemical ID: MESH:D008691
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il4increases expressionISOIL4 (Homo sapiens)6480464CTDMethadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 proteinPMID:23965172
Il4multiple interactionsISOIL4 (Homo sapiens)6480464CTDCTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]PMID:23965172
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