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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737149
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF2
Name: insulin like growth factor 2
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF2multiple interactionsEXP 6480464CTD[Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 proteinPMID:21664031
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