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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736368
Species: Mus musculus
RGD Object: Gene
Symbol: Pdx1
Name: pancreatic and duodenal homeobox 1
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdx1increases expressionEXP 6480464CTDMetformin results in increased expression of PDX1 proteinPMID:16489446
Pdx1multiple interactionsEXP 6480464CTD[Metformin co-treated with Glucose] affects the localization of PDX1 proteinPMID:16489446
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