GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsk3b | decreases expression | ISO | GSK3B (Homo sapiens) | 6480464 | CTD | Metformin results in decreased expression of GSK3B protein modified form | PMID:33838154 | Gsk3b | increases phosphorylation | ISO | GSK3B (Homo sapiens) | 6480464 | CTD | Metformin results in increased phosphorylation of GSK3B protein | PMID:21054339 PMID:26835874 | Gsk3b | multiple interactions | ISO | Gsk3b (Rattus norvegicus) | 6480464 | CTD | Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of GSK3B protein] | PMID:30742852 PMID:31877369 | Gsk3b | multiple interactions | ISO | GSK3B (Homo sapiens) | 6480464 | CTD | AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein] | PMID:30928401 PMID:33651899 PMID:34432352 PMID:35350904 | | ||||||||||||||||||||||
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