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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730826
Species: Homo sapiens
RGD Object: Gene
Symbol: ESRRA
Name: estrogen related receptor alpha
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ESRRAdecreases expressionISOEsrra (Mus musculus)6480464CTDMetformin results in decreased expression of ESRRA mRNAPMID:23166782
ESRRAmultiple interactionsISOEsrra (Mus musculus)6480464CTDMetformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]PMID:23166782
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