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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69473
Species: Homo sapiens
RGD Object: Gene
Symbol: SREBF1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SREBF1multiple interactionsEXP 6480464CTD[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein]PMID:28576465 PMID:36529352 PMID:36764371
SREBF1decreases expressionISOSrebf1 (Rattus norvegicus)6480464CTDMetformin results in decreased expression of SREBF1 mRNAPMID:31324951
SREBF1multiple interactionsISOSrebf1 (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 protein]PMID:31100278
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