GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | multiple interactions | EXP | | 6480464 | CTD | Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] | PMID:29095437 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Metformin results in increased cleavage of PARP1 protein | PMID:35350904 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Metformin results in increased expression of PARP1 mRNA | PMID:29117515 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; plantamajoside promotes the reaction [Metformin results in increased cleavage of PARP1 protein]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA] | PMID:29117515 PMID:35350904 | Parp1 | multiple interactions | ISO | Parp1 (Rattus norvegicus) | 6480464 | CTD | Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein] | PMID:27551045 | | ||||||||||||||||||||||
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