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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351472
Species: Homo sapiens
RGD Object: Gene
Symbol: ADIPOQ
Name: adiponectin, C1Q and collagen domain containing
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADIPOQdecreases expressionEXP 6480464CTDMetformin results in decreased expression of ADIPOQ mRNAPMID:20956498
ADIPOQmultiple interactionsEXP 6480464CTDCimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]PMID:20956498
ADIPOQincreases expressionISOAdipoq (Rattus norvegicus)6480464CTDMetformin results in increased expression of ADIPOQ proteinPMID:30256492
ADIPOQmultiple interactionsISOAdipoq (Mus musculus)6480464CTDMetformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]PMID:32652086 PMID:37337224
ADIPOQmultiple interactionsISOAdipoq (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]PMID:25108154
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