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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10766
Species: Mus musculus
RGD Object: Gene
Symbol: Igf1r
Name: insulin-like growth factor I receptor
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R protein]PMID:26492952 PMID:36547818
Igf1rmultiple interactionsISOIGF1R (Homo sapiens)6480464CTD[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNAPMID:21664031
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