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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10127
Species: Mus musculus
RGD Object: Gene
Symbol: Ahr
Name: aryl-hydrocarbon receptor
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects activityISOAhr (Rattus norvegicus)6480464CTDMetformin affects the activity of AHR proteinPMID:25596134
Ahrdecreases expressionISOAHR (Homo sapiens)6480464CTDMetformin results in decreased expression of AHR mRNA; Metformin results in decreased expression of AHR proteinPMID:25110054
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDMetformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]PMID:25110054 PMID:25697376
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