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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:67989
Term: ginsenoside Rb1
Definition: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group.
Chemical ID: MESH:C442759
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1increases expressionISORGD:7309016480464CTDginsenoside Rb1 results in increased expression of HMOX1 mRNA

PMID:19781563
Hmox1multiple interactionsISORGD:107176480464CTD[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein

PMID:25422538
Hmox1multiple interactionsISORGD:7309016480464CTD2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein] Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA] Cycloheximide inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein] Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA] Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein] fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA] fulvestrant inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein] ginsenoside Rb1 results in increased expression of and results in increased activity of HMOX1 protein Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA] Pertussis Toxin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]

PMID:19781563
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