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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:67987
Term: ginsenoside Rg1
Definition: A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position.
Chemical ID: MESH:C035054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]PMID:34859534
Baxincreases expressionISOBax (Mus musculus)6480464CTDginsenoside Rg1 results in increased expression of BAX proteinPMID:28371286
Baxmultiple interactionsISOBax (Mus musculus)6480464CTDginsenoside Rg1 inhibits the reaction [Chlorpyrifos results in increased expression of BAX protein]PMID:36811218
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of BAX mRNA]PMID:34783124
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