Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	737569
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	APOC3
Name:	apolipoprotein C3

Acc ID:	CHEBI:67986
Term:	ginsenoside Rf
Definition:	A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
Chemical ID:	MESH:C055328

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
APOC3	decreases expression	ISO	Apoc3 (Mus musculus)	6480464	CTD	ginsenoside Rf results in decreased expression of APOC3 protein	PMID:16297877
APOC3	increases expression	ISO	Apoc3 (Mus musculus)	6480464	CTD	ginsenoside Rf results in increased expression of APOC3 mRNA	PMID:16297877
APOC3	multiple interactions	ISO	Apoc3 (Mus musculus)	6480464	CTD	ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]	PMID:16297877

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