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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6v1
Name: cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
Acc ID: CHEBI:6757
Term: mephenytoin
Definition: An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Chemical ID: MESH:D008617
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6v1affects hydroxylationISORGD:7374166480464CTDCYP2C19 gene SNP affects the hydroxylation of Mephenytoin CYP2C19 protein affects the hydroxylation of Mephenytoin

PMID:9170147
Cyp2c6v1affects metabolic processingISORGD:7374166480464CTDCYP2C19 protein affects the metabolism of Mephenytoin

PMID:3577206
Cyp2c6v1decreases activityISORGD:7374166480464CTDMephenytoin results in decreased activity of CYP2C19 protein

PMID:12467917
Cyp2c6v1increases hydroxylationISORGD:7374166480464CTDCYP2C19 protein results in increased hydroxylation of Mephenytoin

PMID:12433797 PMID:12637241 PMID:15258107 PMID:15618748 PMID:15860655 PMID:22652334 PMID:28762043 PMID:29445054
Cyp2c6v1increases metabolic processingISORGD:7374166480464CTDCYP2C19 protein results in increased metabolism of Mephenytoin

PMID:11907490 PMID:12401345 PMID:12464242 PMID:12569440 PMID:15043991 PMID:15155557 PMID:15370959 PMID:16049126 PMID:16124035 PMID:17267297 PMID:17418993 PMID:18979093 PMID:21915887 PMID:23721565 PMID:23850985 PMID:25084468 PMID:28119166
Cyp2c6v1increases oxidationISORGD:7374166480464CTDCYP2C19 protein results in increased oxidation of Mephenytoin

PMID:17478480 PMID:19053182 PMID:21964418
Cyp2c6v1multiple interactionsISORGD:7374166480464CTD4-amino-2-phenoxymethanesulfonanilide inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin] [CYP2C19 protein results in increased metabolism of Mephenytoin] which results in increased chemical synthesis of 4-hydroxymephenytoin [Mephenytoin results in decreased activity of CYP2C19 protein] which results in decreased degradation of vanoxerine Fluoxetine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] Fluoxetine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] GH1 protein inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] Mephenytoin inhibits the reaction [CYP2C19 protein results in increased metabolism of 4 5-dihydropyrazole-1 5-dicarboxylic acid 1-4-chlorophenyl-amide 5-2-oxo-2H-1 3'bipyridinyl-6'-yl-amide] Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] Pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] perfluorooctane sulfonic acid inhibits the reaction [CYP2C19 protein results in increased oxidation of Mephenytoin] rabeprazole-thioether inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] Resveratrol inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] sitaxsentan inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] Ticlopidine inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] Ticlopidine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] Tranylcypromine inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] ursolic acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin] zafirlukast inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]

PMID:11502731 PMID:11907490 PMID:12569440 PMID:15043991 PMID:15258107 PMID:15370959 PMID:16049126 PMID:19053182 PMID:19697924 PMID:21915887 PMID:21964418 PMID:22652334 PMID:23721565 PMID:23850985 PMID:25084468 PMID:28119166
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