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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308166
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c79
Name: cytochrome P450, family 2, subfamily c, polypeptide 79
Acc ID: CHEBI:6757
Term: mephenytoin
Definition: An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Chemical ID: MESH:D008617
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c79decreases activityISORGD:7341576480464CTDMephenytoin results in decreased activity of CYP2C29 protein

PMID:18420780
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