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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344671
Species: Homo sapiens
RGD Object: Gene
Symbol: TFF1
Name: trefoil factor 1
Acc ID: CHEBI:67547
Term: alpha-mangostin
Definition: A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.
Chemical ID: MESH:C021053
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFF1decreases expressionEXP 6480464CTDmangostin results in decreased expression of TFF1 proteinPMID:24480042
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