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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70896
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ces1d
Name: carboxylesterase 1D
Acc ID: CHEBI:6754
Term: pethidine
Definition: A piperidinecarboxylate ester that is piperidine which is substituted by a methyl group at position 1 and by phenyl and ethoxycarbonyl groups at position 4. It is an analgesic which is used for the treatment of moderate to severe pain, including postoperative pain and labour pain.
Chemical ID: MESH:D008614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ces1daffects bindingISORGD:13529606480464CTDMeperidine binds to CES1 protein

PMID:10381793
Ces1dincreases hydrolysisISORGD:13529606480464CTDCES1 protein results in increased hydrolysis of Meperidine

PMID:10381793
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