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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733293
Species: Homo sapiens
RGD Object: Gene
Symbol: APAF1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APAF1multiple interactionsISOApaf1 (Rattus norvegicus)6480464CTDMelitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein]PMID:21354845
APAF1multiple interactionsISOApaf1 (Mus musculus)6480464CTDMelitten affects the reaction [TGFB1 protein affects the localization of APAF1 protein]PMID:21871910
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