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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hrh2
Name: histamine receptor H 2
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrh2increases activityEXP 6480464CTDMelitten results in increased activity of HRH2 protein

PMID:22995146
Hrh2increases response to substanceEXP 6480464CTDHRH2 protein results in increased susceptibility to Melitten

PMID:22995146
Hrh2multiple interactionsEXP 6480464CTDRanitidine inhibits the reaction [Melitten results in increased activity of HRH2 protein]

PMID:22995146
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