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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342640
Species: Homo sapiens
RGD Object: Gene
Symbol: SCN11A
Name: sodium voltage-gated channel alpha subunit 11
Acc ID: CHEBI:6736
Term: melittin
Definition: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active component of bee venom.
Chemical ID: MESH:D008555
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SCN11Aincreases expressionISOScn11a (Rattus norvegicus)6480464CTDMelitten results in increased expression of SCN11A mRNA; Melitten results in increased expression of SCN11A proteinPMID:23264124
SCN11Aincreases response to substanceISOScn11a (Rattus norvegicus)6480464CTDSCN11A protein results in increased susceptibility to MelittenPMID:23264124
SCN11Amultiple interactionsISOScn11a (Rattus norvegicus)6480464CTD[Melitten results in increased expression of SCN11A protein] which results in increased transport of SodiumPMID:23264124
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