GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | perifosine results in increased expression of CASP8 protein modified form | PMID:32587277 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with Vorinostat] results in increased activity of CASP8 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form] | PMID:15781658 PMID:32587277 | | ||||||||||||||||||||||
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