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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69123
Species: Homo sapiens
RGD Object: Gene
Symbol: LEP
Name: leptin
Acc ID: CHEBI:67271
Term: MK-2206
Definition: An organic heterotricyclic compound that is [1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one substituted at positions 8 and 9 respectively by 4-(1-aminocyclobutyl)phenyl and phenyl groups.
Chemical ID: MESH:C548887
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LEPmultiple interactionsISOLep (Mus musculus)6480464CTDMK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein]PMID:27381457
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