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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564091
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Greb1
Name: growth regulating estrogen receptor binding 1
Acc ID: CHEBI:6723
Term: megestrol acetate
Definition: A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer.
Chemical ID: MESH:D019290
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Greb1increases expressionISOGREB1 (Homo sapiens)6480464CTDMegestrol Acetate results in increased expression of GREB1 mRNAPMID:33405908
Greb1multiple interactionsISOGREB1 (Homo sapiens)6480464CTDESR1 protein affects the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA]PMID:33405908
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