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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589149
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gba
Name: glucosylceramidase beta
Acc ID: CHEBI:67229
Term: conduritol B epoxide
Definition: A racemate comprising the 1-D- and 1-L- enantiomers of 1,2-anhydro-myo-inositol.
Chemical ID: MESH:C011423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gbadecreases activityEXP 6480464CTDconduritol epoxide analog results in decreased activity of GBA protein

PMID:9101438
Gbamultiple interactionsISORGD:16070896480464CTD[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein

PMID:19576930
Gbamultiple interactionsISORGD:16233106480464CTD[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein, [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein

PMID:19576930
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.