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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735711
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A2
Name: cytochrome P450 family 1 subfamily A member 2
Acc ID: CHEBI:6717
Term: mefenamic acid
Definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Chemical ID: MESH:D008528
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A2decreases activityEXP 6480464CTDMefenamic Acid results in decreased activity of CYP1A2 proteinPMID:18816299
CYP1A2increases glutathionylationEXP 6480464CTDCYP1A2 protein results in increased glutathionylation of Mefenamic Acid analogPMID:25372302
CYP1A2increases hydroxylationEXP 6480464CTDCYP1A2 protein results in increased hydroxylation of Mefenamic AcidPMID:25372302
CYP1A2increases oxidationEXP 6480464CTDCYP1A2 protein results in increased oxidation of Mefenamic AcidPMID:33259822
CYP1A2multiple interactionsEXP 6480464CTDSOD1 protein inhibits the reaction [CYP1A2 protein results in increased oxidation of Mefenamic Acid]PMID:33259822
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