Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3767
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sult1a1
Name: sulfotransferase family 1A member 1
Acc ID: CHEBI:6717
Term: mefenamic acid
Definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
Chemical ID: MESH:D008528
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sult1a1multiple interactionsEXP 6480464CTDMefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of Dopamine]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of salicylamide]PMID:11181495
Sult1a1decreases activityISOSULT1A1 (Homo sapiens)6480464CTDMefenamic Acid results in decreased activity of SULT1A1 proteinPMID:29596660
Sult1a1multiple interactionsISOSULT1A1 (Homo sapiens)6480464CTD[Mefenamic Acid results in decreased activity of SULT1A1 protein] which results in decreased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of Dopamine]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of harmol]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin]; Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of salicylamide]PMID:11181495 PMID:29596660
Go Back to source page   Continue to Ontology report