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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731081
Species: Homo sapiens
RGD Object: Gene
Symbol: PGR
Name: progesterone receptor
Acc ID: CHEBI:6716
Term: medroxyprogesterone acetate
Definition: A steroid ester that has formula C24H34O4.
Chemical ID: MESH:D017258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMedroxyprogesterone Acetate results in decreased expression of PGR mRNA, Medroxyprogesterone Acetate results in decreased expression of PGR protein

PMID:20843944, PMID:23183084
multiple interactionsEXP 6480464CTDMedroxyprogesterone Acetate promotes the reaction [PGR protein binds to NCOA1 protein]

PMID:15937332
decreases expressionISORGD:110926480464CTDMedroxyprogesterone Acetate results in decreased expression of PGR protein

PMID:2151368
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.