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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:6709
Term: Meclizine
Definition: A diarylmethane that has formula C25H27ClN2.
Chemical ID: MESH:D008468
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9multiple interactionsISOCYP3A5 (Homo sapiens)6480464CTDMeclizine inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Meclizine inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]PMID:26239802
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