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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619713
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cnr2
Name: cannabinoid receptor 2
Acc ID: CHEBI:67078
Term: Delta(9)-tetrahydrocannabinolic acid
Definition: A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. A biosynthetic precursor to Delta(9)-tetrahydrocannabinol, the principal psychoactive constituent of the cannabis plant.
Chemical ID: MESH:C025351
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cnr2multiple interactionsISOCNR2 (Homo sapiens)6480464CTDdelta(9)-tetrahydrocannabinolic acid inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein]; delta(9)-tetrahydrocannabinolic acid inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) binds to CNR2 protein]PMID:28861508 PMID:32510591
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