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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621325
Species: Rattus norvegicus
RGD Object: Gene
Symbol: As3mt
Name: arsenite methyltransferase
Acc ID: CHEBI:67040
Term: S-adenosyl-L-methioninate
Definition: A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:13506976480464CTDAS3MT protein binds to S-Adenosylmethionine

PMID:22955273, PMID:25349987
multiple interactionsISORGD:13506976480464CTDCysteine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine], Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine], S-Adenosylmethionine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite], tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]

PMID:22955273, PMID:25349987
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.