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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736829
Species: Homo sapiens
RGD Object: Gene
Symbol: SHH
Name: sonic hedgehog signaling molecule
Acc ID: CHEBI:66903
Term: vismodegib
Definition: A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Chemical ID: MESH:C538724
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SHHmultiple interactionsEXP 6480464CTDHhAntag691 inhibits the reaction [AGT protein results in increased expression of SHH protein]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA]PMID:31181250 PMID:31642701
SHHdecreases expressionISOShh (Mus musculus)6480464CTDHhAntag691 results in decreased expression of SHH mRNAPMID:27585885
SHHmultiple interactionsISOShh (Mus musculus)6480464CTDGLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]PMID:27585885
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