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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdgfra
Name: platelet derived growth factor receptor alpha
Acc ID: CHEBI:66903
Term: vismodegib
Definition: A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Chemical ID: MESH:C538724
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdgfradecreases expressionISOPDGFRA (Homo sapiens)6480464CTDHhAntag691 results in decreased expression of PDGFRA proteinPMID:22087285
Pdgframultiple interactionsISOPDGFRA (Homo sapiens)6480464CTD[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]PMID:22087285
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