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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1556878
Species: Mus musculus
RGD Object: Gene
Symbol: Sufu
Name: SUFU negative regulator of hedgehog signaling
Acc ID: CHEBI:66903
Term: vismodegib
Definition: A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Chemical ID: MESH:C538724
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sufuincreases expression ISOSUFU (Homo sapiens)150573695RGDvismodegib increases SUFU protein expression in pituitary adenoma cells 
Sufumultiple interactionsEXP 6480464CTDHhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]PMID:24973920
Sufudecreases response to substanceISOSUFU (Homo sapiens)6480464CTDSUFU gene mutant form results in decreased susceptibility to HhAntag691PMID:24973920
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