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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319523
Species: Mus musculus
RGD Object: Gene
Symbol: Gli2
Name: GLI-Kruppel family member GLI2
Acc ID: CHEBI:66903
Term: vismodegib
Definition: A benzamide obtained by formal condensation between the carboxy group of 2-chloro-4-(methylsulfonyl)benzoic acid and the anilino group of 4-chloro-3-(pyridin-2-yl)aniline. Used for the treatment metastatic basal cell carcinoma.
Chemical ID: MESH:C538724
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gli2decreases expressionEXP 6480464CTDHhAntag691 results in decreased expression of GLI2 mRNAPMID:24973920
Gli2increases response to substanceEXP 6480464CTDGLI2 gene mutant form results in increased susceptibility to HhAntag691PMID:27585885
Gli2multiple interactionsEXP 6480464CTDGLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA]PMID:24973920 PMID:27585885
Gli2decreases expressionISOGLI2 (Homo sapiens)6480464CTDHhAntag691 results in decreased expression of GLI2 mRNAPMID:22087285
Gli2decreases response to substanceISOGLI2 (Homo sapiens)6480464CTDGLI2 protein results in decreased susceptibility to HhAntag691PMID:24973920
Gli2multiple interactionsISOGLI2 (Homo sapiens)6480464CTD[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein]PMID:22087285 PMID:31181250
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