GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gli2 | decreases expression | EXP | | 6480464 | CTD | HhAntag691 results in decreased expression of GLI2 mRNA | PMID:24973920 | Gli2 | increases response to substance | EXP | | 6480464 | CTD | GLI2 gene mutant form results in increased susceptibility to HhAntag691 | PMID:27585885 | Gli2 | multiple interactions | EXP | | 6480464 | CTD | GLI2 gene mutant form promotes the reaction [HhAntag691 inhibits the reaction [SHH protein results in increased expression of PTCH1 mRNA]]; HhAntag691 inhibits the reaction [SUFU gene mutant form results in increased expression of GLI2 mRNA] | PMID:24973920 PMID:27585885 | Gli2 | decreases expression | ISO | GLI2 (Homo sapiens) | 6480464 | CTD | HhAntag691 results in decreased expression of GLI2 mRNA | PMID:22087285 | Gli2 | decreases response to substance | ISO | GLI2 (Homo sapiens) | 6480464 | CTD | GLI2 protein results in decreased susceptibility to HhAntag691 | PMID:24973920 | Gli2 | multiple interactions | ISO | GLI2 (Homo sapiens) | 6480464 | CTD | [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of BCL2 protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of FAS protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10A protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in increased expression of TNFRSF10B protein]; [GLI1 mRNA co-treated with GLI2 mRNA] affects the susceptibility to HhAntag691; HhAntag691 inhibits the reaction [AGT protein results in increased expression of GLI2 protein] | PMID:22087285 PMID:31181250 | |
Go Back to source page | Continue to Ontology report |