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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:6682
Term: mangiferin
Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Chemical ID: MESH:C013592
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAaffects localizationEXP 6480464CTDmangiferin affects the localization of RELA proteinPMID:26996543
RELAdecreases localizationEXP 6480464CTDmangiferin results in decreased localization of RELA proteinPMID:21547680
RELAmultiple interactionsEXP 6480464CTDmangiferin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein]PMID:15161907
RELAdecreases expressionISORela (Mus musculus)6480464CTDmangiferin results in decreased expression of RELA mRNAPMID:15135318
RELAmultiple interactionsISORela (Mus musculus)6480464CTDmangiferin analog inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; mangiferin inhibits the reaction [lead nitrate results in increased expression of RELA protein]; mangiferin inhibits the reaction [Scopolamine results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [TNFSF11 protein results in increased localization of RELA protein]PMID:19182383 PMID:20683903 PMID:23451106 PMID:27474068
RELAmultiple interactionsISORela (Rattus norvegicus)6480464CTD2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in increased expression of and results in increased phosphorylation of RELA protein]]; mangiferin inhibits the reaction [Excitatory Amino Acid Agonists affects the localization of and results in increased activity of RELA protein]; mangiferin inhibits the reaction [Galactosamine results in increased expression of RELA protein]; mangiferin inhibits the reaction [Methotrexate results in increased expression of and results in increased phosphorylation of RELA protein]; mangiferin inhibits the reaction [Streptozocin results in increased expression of RELA mRNA]PMID:19201465 PMID:22310181 PMID:36249937 PMID:37044004
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