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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:6682
Term: mangiferin
Definition: A C-glycosyl compound consisting of 1,3,6,7-tetrahydroxyxanthen-9-one having a beta-D-glucosyl residue at the 6-position.
Chemical ID: MESH:C013592
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:13500186480464CTDmangiferin results in decreased activity of UGT1A1 protein

PMID:22815239
increases expressionISORGD:13500186480464CTDmangiferin results in increased expression of UGT1A1 mRNA

PMID:22815239
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.